Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner
نویسندگان
چکیده
منابع مشابه
Tissue-engineered heart valves.
Currently-used mechanical and biological heart valve prostheses have several disadvantages. Mechanical prostheses, based on carbon, metallic and polymeric components, require permanent anticoagulation treatment, and their usage often leads to adverse reactions, e.g. thromboembolic complications and endocarditis. Xenogenous and allogenous biological prostheses are associated with immune reaction...
متن کاملModeling the mechanics of tissue-engineered human heart valve leaflets.
Mathematical models can provide valuable information to assess and evaluate the mechanical behavior of tissue-engineered constructs. In this study, a structurally based model is applied to describe and analyze the mechanics of tissue-engineered human heart valve leaflets. The results from two orthogonal uniaxial tensile tests are used to determine the model parameters of the constructs after tw...
متن کاملHuman Engineered Heart Tissue: Analysis of Contractile Force
Analyzing contractile force, the most important and best understood function of cardiomyocytes in vivo is not established in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM). This study describes the generation of 3D, strip-format, force-generating engineered heart tissues (EHT) from hiPSC-CM and their physiological and pharmacological properties. CM were differentiated fro...
متن کاملAutologous human tissue-engineered heart valves: prospects for systemic application.
BACKGROUND Tissue engineering represents a promising approach for the development of living heart valve replacements. In vivo animal studies of tissue-engineered autologous heart valves have focused on pulmonary valve replacements, leaving the challenge to tissue engineer heart valves suitable for systemic application using human cells. METHODS AND RESULTS Tissue-engineered human heart valves...
متن کاملEngineered Heart Tissue: A Novel Tool to Study the Ischemic Changes of the Heart In Vitro
BACKGROUND Understanding the basic mechanisms and prevention of any disease pattern lies mainly on development of a successful experimental model. Recently, engineered heart tissue (EHT) has been demonstrated to be a useful tool in experimental transplantation. Here, we demonstrate a novel function for the spontaneously contracting EHT as an experimental model in studying the acute ischemia-ind...
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ژورنال
عنوان ژورنال: Circulation
سال: 2021
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.120.047904